{"id":1563,"date":"2020-11-07T08:00:48","date_gmt":"2020-11-07T08:00:48","guid":{"rendered":"https:\/\/barcelonamedicalphotonics.icfo.eu\/?post_type=portfolio&p=1563"},"modified":"2021-02-19T14:32:50","modified_gmt":"2021-02-19T14:32:50","slug":"perfils-moleculars-i-micro-espectroscopics-integrals-de-carcinomes-de-mama","status":"publish","type":"portfolio","link":"https:\/\/barcelonamedicalphotonics.icfo.eu\/ca\/portfolio\/perfils-moleculars-i-micro-espectroscopics-integrals-de-carcinomes-de-mama\/","title":{"rendered":"Perfils moleculars i micro-espectrosc\u00f2pics integrals de carcinomes de mama"},"content":{"rendered":"\n
\n
\n
\n
\n
<\/div>\n\n\n\n

Investigadors de l’Institut de Recerca Germans Trias i Pujol i l’ICFO treballen junts per combatre el c\u00e0ncer de mama.<\/h2>\n\n\n\n

https:\/\/jointlab-sjd.icfo.eu\/ca\/inici\/<\/a><\/p>\n\n\n\n

<\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n

Socis de la xarxa i investigadors clau implicats en el projecte<\/h3>\n\n\n\n
<\/div>\n\n\n\n
\n
\n
\"\"<\/figure>\n<\/div><\/div>\n\n\n\n
\n

M\u00f3nica Marro S\u00e1nchez
Pablo Loza- Alvarez<\/a><\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n

<\/div>\n\n\n\n
\n\n\n\n
\n
\n
\"\"<\/figure>\n<\/div><\/div>\n\n\n\n
\n
<\/div>\n\n\n\n

Pedro Luis Fern\u00e1ndez Ruiz
Ana Mar\u00eda Mu\u00f1oz M\u00e1rmol
Carolina Sanz Monte
Laura Hern\u00e1ndez Le\u00f3n
Laura Pons Mart\u00ednez
Montse Tierno Garc\u00eda
Mireia Margel\u00ed Vila
Vanesa Quiroga Garc\u00eda
Eudald Felip Falgas<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n

<\/div>\n\n\n\n
\n
\n

Resum del projecte<\/h3>\n\n\n\n
<\/div>\n\n\n\n

El tractament neoadjuvant \u00e9s una estrat\u00e8gia cada vegada m\u00e9s utilitzada en carcinomes de mama (breast carcinomas en angl\u00e8s, BC), especialment en els subtipus Her2 positius i triple negatius (TNBC) aconseguint una taxa de respostes completes patol\u00f2giques al voltant del 30-50% dels casos segons diferents estudis Aix\u00f2 ha suposat un gran avan\u00e7 en el pron\u00f2stic d’aquesta malaltia a l’associar-se a una major superviv\u00e8ncia en aquests subtipus. No obstant aix\u00f2, un percentatge de pacients no responen b\u00e9 a la neoadjuv\u00e0ncia, quedant per aclarir en gran mesura els mecanismes subjacents a la resist\u00e8ncia a aquest tipus de tractament. Entre ells es comencen a con\u00e8ixer certes alteracions gen\u00e8tiques i fenot\u00edpiques encara escassament definides.<\/p>\n\n\n\n

En aquest projecte analitzem una s\u00e8rie de pacients amb carcinomes mamaris infiltrants primaris que inclour\u00e0 casos retrospectius i prospectius de fenotips Her2 +, triples negatius i luminals B tractats amb quimioter\u00e0pia neoadjuvant i que constar\u00e0 de responedors bons (resposta patol\u00f2gica completa, o RPC) i dolents, en els quals s’analitzar\u00e0 l’exist\u00e8ncia d’alteracions en diversos processos i vies per mitj\u00e0 d’un panell ampli de gens amb una plataforma multig\u00e8nica (nCounter, Nanostring). Aquesta caracteritzaci\u00f3 transcripcional es realitzar\u00e0 en mostres de bi\u00f2psia pre-tractament i, en els casos sense RPC, en tumors residuals. Alguns casos tindran met\u00e0stasi a dist\u00e0ncia aparellades, el que permetr\u00e0 una tipificaci\u00f3 al llarg de diverses fases de la progressi\u00f3 tumoral. S’analitzar\u00e0 el tipus de resposta inflamat\u00f2ria pre- i post tractament aix\u00ed com l’expressi\u00f3 del marcador PDL1 en c\u00e8l\u00b7lules tumorals i inflamat\u00f2ries. Les troballes moleculars es validaran en models in vitro i in vivo sobre l\u00ednies cel\u00b7lulars de c\u00e0ncer de mama na\u00efve i resistents a la ter\u00e0pia. S’estudiar\u00e0 l’\u00fas de la microespectroscopia Raman per al tipatge de mostres de mama i el seu \u00fas en entorn cl\u00ednic.<\/p>\n\n\n\n

<\/div>\n\n\n\n

<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n

<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n

\n
\n

Highlighted publications <\/h3>\n\n\n\n

Link to publication n\u00ba1
\u2029Link to publication n\u00ba2
\u2029Link to publication n\u00ba3\u2029
Link to publication n\u00ba4
\u2029Link to publication n\u00ba5<\/a><\/p>\n\n\n\n

<\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n
\n
\n

Not\u00edcies relacionades <\/strong><\/h3>\n\n\n\n
<\/div>\n\n\n\n

La Marat\u00f3 de TV3 2018 funds research on cancer <\/a><\/p>\n\n\n\n

<\/div>\n\n\n\n

<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n

\n
\n

Finan\u00e7ament<\/h3>\n\n\n\n
\n
\n
\"\"<\/figure>\n<\/div><\/div>\n\n\n\n
\n
\"\"<\/figure>\n<\/div><\/div>\n\n\n\n
\n
<\/div>\n\n\n\n
\"\"<\/figure>\n<\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

Investigadors de l’Institut de Recerca Germans Trias i Pujol i l’ICFO treballen junts per combatre el c\u00e0ncer de mama.<\/p>\n","protected":false},"author":6,"featured_media":1641,"parent":0,"menu_order":5,"template":"","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":1,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"portfolio-type":[],"class_list":["post-1563","portfolio","type-portfolio","status-publish","has-post-thumbnail","entry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/barcelonamedicalphotonics.icfo.eu\/ca\/wp-json\/wp\/v2\/portfolio\/1563","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/barcelonamedicalphotonics.icfo.eu\/ca\/wp-json\/wp\/v2\/portfolio"}],"about":[{"href":"https:\/\/barcelonamedicalphotonics.icfo.eu\/ca\/wp-json\/wp\/v2\/types\/portfolio"}],"author":[{"embeddable":true,"href":"https:\/\/barcelonamedicalphotonics.icfo.eu\/ca\/wp-json\/wp\/v2\/users\/6"}],"version-history":[{"count":13,"href":"https:\/\/barcelonamedicalphotonics.icfo.eu\/ca\/wp-json\/wp\/v2\/portfolio\/1563\/revisions"}],"predecessor-version":[{"id":2077,"href":"https:\/\/barcelonamedicalphotonics.icfo.eu\/ca\/wp-json\/wp\/v2\/portfolio\/1563\/revisions\/2077"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/barcelonamedicalphotonics.icfo.eu\/ca\/wp-json\/wp\/v2\/media\/1641"}],"wp:attachment":[{"href":"https:\/\/barcelonamedicalphotonics.icfo.eu\/ca\/wp-json\/wp\/v2\/media?parent=1563"}],"wp:term":[{"taxonomy":"portfolio-type","embeddable":true,"href":"https:\/\/barcelonamedicalphotonics.icfo.eu\/ca\/wp-json\/wp\/v2\/portfolio-type?post=1563"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}